Tired of feeling depleted?

Missing life’s best moment because you’re running low on energy?

You’re not alone.

As you age, vital nutrients like NAD+ begin to decrease as your body finds it harder to keep functioning at a high level and fatigue takes over.

That’s where Ageless Life comes in.

A 100% kiwi owned business here to help with sleep, stamina, libido, and the list goes on.

Our Pure NMN Powder Pouches contain pure premium grade NMN powder.

NMN supports healthy NAD+ levels, so you can target age-related decline at the cellular level, turn back the clock and have more than enough energy for what matters.

Delivered in one, easy-to-take powder trusted by thousands.

Try NMN for 60 days and see results, or get your money back.

We ship all orders from our New Zealand based headquarters based at Remuera Auckland NZ, We are a proud Kiwi owned business

One of the key molecules that regulates DNA repair is NAD+ (nicotinamide adenine dinucleotide), a coenzyme that is involved in many cellular functions, such as energy metabolism, gene expression, and cell survival. NAD+ levels also decline with age, which impairs the activity of enzymes that depend on NAD+, such as sirtuins and PARP1. Sirtuins are proteins that modulate the epigenome, which is the set of chemical marks that control gene expression. PARP1 is an enzyme that repairs single-strand and double-strand breaks in DNA.

Therefore, boosting NAD+ levels may be a way to support your body’s natural DNA repair system to prevent or reverse age-related diseases. One of the strategies to increase NAD+ levels is to supplement with its precursors, such as NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) by taking xtralife’s Rewind product. NMN and NR are molecules that can be converted into NAD+ in the cells. NMN and NR are found in small amounts in natural foods, such as milk, vegetables, and meats, but they can also be taken as Rewind supplement.

NMN is one step closer to NAD+ than NR in the biosynthesis pathway. NMN can enter the cells through a specific transporter called Slc12a8 and then be converted into NAD+. By increasing NAD+ levels, NMN can activate sirtuins and PARP1, which can improve DNA repair and epigenetic maintenance.

Several studies have shown that NMN can support normal DNA repair in different ways. For example:

• A study by Li et al. showed that NMN can protect human embryonic kidney cells from oxidative stress-induced DNA damage by increasing NAD+ levels and activating SIRT1.
• A study by Zhang et al. showed that NMN can reduce DNA damage and apoptosis in human lung epithelial cells exposed to the spike protein of SARS-CoV-2 by increasing NAD+ levels and activating PARP1.
• A study by Mills et al. showed that NMN can restore DNA repair capacity in old mice by increasing NAD+ levels and activating SIRT6.

NR is converted into NMN, and then NMN is used to build NAD+. By increasing NAD+ levels, NR can also activate sirtuins and PARP1, which can enhance DNA repair and epigenetic maintenance.

Several studies have shown that NR can support normal DNA repair in different ways. For example:

• A study by Fang et al. showed that NR can protect human skin cells from UV-induced DNA damage by increasing NAD+ levels and activating SIRT1.
• A study by Katsyuba et al. showed that NR can improve mitochondrial DNA repair in mouse liver cells by increasing NAD+ levels and activating SIRT3.
• A study by Trammell et al. showed that NR can reduce DNA damage and inflammation in mouse muscle cells by increasing NAD+ levels and activating SIRT1.

As we are getting older we need to be more careful what we are doing with our bodies.

A new study claims that taking high dosages of NMN for a long time may increase risk of stroke and heart attack.

Based on current research, the recommended dose of NMN is 250-500mg for those aged under 50, and 500mg for those aged 50-65 and 750mg per day for those aged over 65.

Studies have shown that 1200mg daily for 6 weeks is safe and 900mg daily for 8 weeks, but a recent study in
Nature Medicine (2024) by Ferrell et al from Cleveland Clinic investigated the effects of niacin (Vitamin B3) which is related to NMN.

Researchers found that when niacin is broken down that one of its metabolites 4PY can activate inflammatory pathways potentially leading to arterial plaque.

We suggest capping dose at 500-600mg daily if using long term.

We recommend taking breaks, and exploring our other formulas for enhancing longevity via alternative mechanisms.

NMN is a wonderful technology, but that doesn’t mean that taking high doses every day will make you live
forever.

There is more to longevity than JUST taking NMN.

If you really like the effects of scientifically supported natural compounds and want to support your longevity and health to a greater degree, have a look at using our other products to come at your longevity from some other angles and keep other areas of your body clean and restored.

Join our community and subscribe to our information updates and keep trying new things!

Ref: https://www.nature.com/articles/s41591-023-02793-8